{"id":77834,"date":"2018-09-17T09:34:25","date_gmt":"2018-09-17T08:34:25","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/"},"modified":"2018-09-17T09:34:25","modified_gmt":"2018-09-17T08:34:25","slug":"mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases","status":"publish","type":"post","link":"https:\/\/cri1149.mlcom-dev.net\/en\/news\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/","title":{"rendered":"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases."},"content":{"rendered":"<h3>Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases.<\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Mansouri%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30012333\">Mansouri A<\/a>1,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Gattolliat%20CH%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30012333\">Gattolliat CH<\/a>1,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Asselah%20T%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30012333\">Asselah T<\/a>2.<\/p>\n<h3>Abstract<\/h3>\n<p style=\"text-align: justify;\">Mitochondria regulate hepatic lipid metabolism and oxidative stress. Ultrastructural mitochondrial lesions, altered mitochondrial dynamics, decreased activity of respiratory chain complexes, and impaired ability to synthesize adenosine triphosphate are observed in liver tissues from patients with alcohol-associated and non-associated liver diseases. Increased lipogenesis with decreased fatty acid \u03b2-oxidation leads to the accumulation of triglycerides in hepatocytes, which, combined with increased levels of reactive oxygen species, contributes to insulin resistance in patients with steatohepatitis. Moreover, mitochondrial reactive oxygen species mediate metabolic pathway signaling; alterations in these pathways affect development and progression of chronic liver diseases. Mitochondrial stress and lesions promote cell death, liver fibrogenesis, inflammation, and the innate immune responses to viral infections. We review the involvement of mitochondrial processes in development of chronic liver diseases, such as nonalcoholic fatty, alcohol-associated, and drug-associated liver diseases, as well as hepatitis B and C, and discuss how they might be targeted therapeutically.<\/p>\n<h4><a href=\"http:\/\/www.cri1149.fr\/wp-content\/uploads\/2018\/09\/Asselah-publi2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Asselah publi<\/a><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases.<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[327],"tags":[],"class_list":["post-77834","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. - CRI\" \/>\n<meta property=\"og:description\" content=\"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-17T08:34:25+00:00\" \/>\n<meta name=\"author\" content=\"Philippe\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Philippe\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en#article\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en\"},\"author\":{\"name\":\"Philippe\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/person\/675c235c80b797390cb245d61bd5f395\"},\"headline\":\"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases.\",\"datePublished\":\"2018-09-17T08:34:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en\"},\"wordCount\":173,\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/actuetu\/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases\/?lang=en\",\"name\":\"Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. - 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