{"id":77903,"date":"2021-03-02T17:46:07","date_gmt":"2021-03-02T16:46:07","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/"},"modified":"2021-03-02T17:46:07","modified_gmt":"2021-03-02T16:46:07","slug":"basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin","status":"publish","type":"post","link":"https:\/\/cri1149.mlcom-dev.net\/en\/news-of-the-month\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/","title":{"rendered":"Basophils promote barrier dysfunction and resolution in the atopic skin"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 18pt;\"><strong>Abstract<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\">The type 2 cytokine IL-4 promotes atopic dermatitis but also the resolution of inflammation. The function of IL-4 during the resolution of atopic inflammation is poorly known. In a model of calcipotriol induced atopic dermatitis, we show that basophils are systemically activated by TSLP to produce IL-4. Basophils are the main source of IL-4 in the skin in this model, and directed the proliferation and differentiation of keratinocytes to promote an epidermal dysfunction. However, at the same time, basophils derived IL-4 and M-CSF inhibited the accumulation of proinflammatory leucocytes in the skin while promoting the expansion and function of M2-like pro-resolution macrophages. Thus basophils and IL-4 can play both beneficial and detrimental roles at the same time during atopic skin inflammation.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/doi-org.proxy.insermbiblio.inist.fr\/10.1016\/j.jaci.2021.02.018\">https:\/\/doi-org.proxy.insermbiblio.inist.fr\/10.1016\/j.jaci.2021.02.018<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract The type 2 cytokine IL-4 promotes atopic dermatitis but also the resolution of inflammation. The function of IL-4 during the resolution of atopic inflammation is poorly known. In a model of calcipotriol induced atopic dermatitis, we show that basophils are systemically activated by TSLP to produce IL-4. Basophils are the main source of IL-4 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[328],"tags":[],"class_list":["post-77903","post","type-post","status-publish","format-standard","hentry","category-news-of-the-month"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Basophils promote barrier dysfunction and resolution in the atopic skin - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Basophils promote barrier dysfunction and resolution in the atopic skin - CRI\" \/>\n<meta property=\"og:description\" content=\"Abstract The type 2 cytokine IL-4 promotes atopic dermatitis but also the resolution of inflammation. The function of IL-4 during the resolution of atopic inflammation is poorly known. In a model of calcipotriol induced atopic dermatitis, we show that basophils are systemically activated by TSLP to produce IL-4. Basophils are the main source of IL-4 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-02T16:46:07+00:00\" \/>\n<meta name=\"author\" content=\"Julien Tourneur-Marsille\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien Tourneur-Marsille\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en#article\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en\"},\"author\":{\"name\":\"Julien Tourneur-Marsille\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/person\/3f4f15a33b1d886f4595933229998c82\"},\"headline\":\"Basophils promote barrier dysfunction and resolution in the atopic skin\",\"datePublished\":\"2021-03-02T16:46:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en\"},\"wordCount\":141,\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"articleSection\":[\"News of the month\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/basophils-promote-barrier-dysfunction-and-resolution-in-the-atopic-skin\/?lang=en\",\"name\":\"Basophils promote barrier dysfunction and resolution in the atopic skin - 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