{"id":77938,"date":"2021-11-18T13:39:29","date_gmt":"2021-11-18T12:39:29","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/"},"modified":"2021-11-18T13:39:29","modified_gmt":"2021-11-18T12:39:29","slug":"the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation","status":"publish","type":"post","link":"https:\/\/cri1149.mlcom-dev.net\/en\/news-of-the-month\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/","title":{"rendered":"The role of endocytic trafficking in antigen T Cell Receptor activation"},"content":{"rendered":"<h2><span style=\"font-size: 10pt;\"><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/?term=Evnouchidou+I&amp;cauthor_id=34592497\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Irini Evnouchidou\">Irini Evnouchidou<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/?term=Caillens+V&amp;cauthor_id=34592497\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Vivien Caillens\">Vivien Caillens<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/?term=Koumantou+D&amp;cauthor_id=34592497\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Despoina Koumantou\">Despoina Koumantou<\/a><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/?term=Saveanu+L&amp;cauthor_id=34592497\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Loredana Saveanu\">Loredana Saveanu<\/a><\/span><\/span><\/h2>\n<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\">Antigen T cell receptors (TCR) recognize antigenic peptides displayed by the major histocompatibility complex (pMHC) and play a critical role in T cell activation. The levels of TCR complexes at the cell surface, where signaling is initiated, depend on the balance between TCR synthesis, recycling and degradation. Cell surface TCR interaction with pMHC leads to receptor clustering and formation of a tight T cell-APC contact, the immune synapse, from which the activated TCR is internalized. While TCR internalization from the immune synapse has been initially considered to arrest TCR signaling, recent evidence support the hypothesis that the internalized receptor continues to signal from specialized endosomes. Here, we review the molecular mechanisms of TCR endocytosis and recycling, both in steady state and after T cell activation. We then discuss the experimental evidence in favor of endosomal TCR signaling and its possible consequences on T cell activation.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/34592497\/\">https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/34592497\/<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Irini Evnouchidou,\u00a0Vivien Caillens,\u00a0Despoina Koumantou,\u00a0Loredana Saveanu Abstract Antigen T cell receptors (TCR) recognize antigenic peptides displayed by the major histocompatibility complex (pMHC) and play a critical role in T cell activation. [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[328],"tags":[],"class_list":["post-77938","post","type-post","status-publish","format-standard","hentry","category-news-of-the-month"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The role of endocytic trafficking in antigen T Cell Receptor activation - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The role of endocytic trafficking in antigen T Cell Receptor activation - CRI\" \/>\n<meta property=\"og:description\" content=\"Irini Evnouchidou,\u00a0Vivien Caillens,\u00a0Despoina Koumantou,\u00a0Loredana Saveanu Abstract Antigen T cell receptors (TCR) recognize antigenic peptides displayed by the major histocompatibility complex (pMHC) and play a critical role in T cell activation. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:published_time\" content=\"2021-11-18T12:39:29+00:00\" \/>\n<meta name=\"author\" content=\"Julien Tourneur-Marsille\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien Tourneur-Marsille\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en#article\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en\"},\"author\":{\"name\":\"Julien Tourneur-Marsille\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/person\/3f4f15a33b1d886f4595933229998c82\"},\"headline\":\"The role of endocytic trafficking in antigen T Cell Receptor activation\",\"datePublished\":\"2021-11-18T12:39:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en\"},\"wordCount\":171,\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"articleSection\":[\"News of the month\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/actualites\/the-role-of-endocytic-trafficking-in-antigen-t-cell-receptor-activation\/?lang=en\",\"name\":\"The role of endocytic trafficking in antigen T Cell Receptor activation - 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