{"id":13437,"date":"2015-05-17T13:58:45","date_gmt":"2015-05-17T12:58:45","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13437"},"modified":"2025-09-11T16:48:05","modified_gmt":"2025-09-11T14:48:05","slug":"cross-presentation-of-cell-associated-antigens-by-mhc-class-i-in-dendritic-cell-subsets","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/cross-presentation-of-cell-associated-antigens-by-mhc-class-i-in-dendritic-cell-subsets\/","title":{"rendered":"Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-13437","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Immunol.","date_de_publication":"20150717","numero_doi":"","equipe":[155],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guti\u00e9rrez-Mart\u00ednez  E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Plan\u00e8s R"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Anselmi G"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Reynolds M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Menezes S"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Adiko AC"},{"texte_libre":false,"auteur-lien":13153,"auteur-text":""},{"texte_libre":false,"auteur-lien":13178,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26236315"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/cross-presentation-of-cell-associated-antigens-by-mhc-class-i-in-dendritic-cell-subsets\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:05+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/cross-presentation-of-cell-associated-antigens-by-mhc-class-i-in-dendritic-cell-subsets\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/cross-presentation-of-cell-associated-antigens-by-mhc-class-i-in-dendritic-cell-subsets\/\",\"name\":\"Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets - 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