{"id":14961,"date":"2019-11-04T13:29:34","date_gmt":"2019-11-04T12:29:34","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=14961"},"modified":"2025-09-11T16:48:02","modified_gmt":"2025-09-11T14:48:02","slug":"a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis\/","title":{"rendered":"A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-14961","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Hepatology.","date_de_publication":"20170801","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bissonnette J"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Altamirano J"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Devue C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Roux O"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Payanc\u00e9 A"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lebrec D"},{"texte_libre":false,"auteur-lien":13027,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ait-Oufella H"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sancho-Bru P"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Caballeria J"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gin\u00e8s P"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Boulanger CM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bataller R"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"Bissonnette J1, Altamirano J2, Devue C3,4, Roux O1, Payanc\u00e9 A1, Lebrec D1,5, Bedossa P5,6,7, Valla D1,5,7, Durand F1,5,7, Ait-Oufella H3,4, Sancho-Bru P8, Caballeria J8,9, Gin\u00e8s P8,9, Boulanger CM3,4, Bataller R10, Rautou PE1,3,4,7.","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28120471"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">The diagnosis of alcoholic hepatitis (AH) often requires a transjugular liver biopsy (TJLB), a procedure that is not always readily accessible. We analyzed plasma biomarkers to estimate the presence of histological features of AH among\u00a0<span class=\"highlight\">patients<\/span>\u00a0with clinical suspicion of AH. Using enzyme-linked immunosorbent assay, we tested M65 and M30 (circulating fragments of cytokeratin-18) and their respective fraction carried by microvesicles (MVs), CCL20 and TREM1. Leukocyte, platelet, and endothelial-derived MVs were quantified by way of flow cytometry. Test and validation cohorts prospectively included\u00a0<span class=\"highlight\">patients<\/span>\u00a0with clinical features of AH undergoing TJLB. In the test cohort, 46 of 83 (55%)\u00a0<span class=\"highlight\">patients<\/span>\u00a0showed histological features of AH. Age, bilirubin, INR, and creatinine (ABIC) score was B or C in 83%.\u00a0<span class=\"highlight\">Patients<\/span>\u00a0with histologically proven AH had higher\u00a0<span class=\"highlight\">levels<\/span>\u00a0of total and MV-bound M65 and total and MV-bound M30 and CCL20 than those without (P &lt; 0.001 for all tests).\u00a0<span class=\"highlight\">Levels<\/span>\u00a0of TREM-1 and of subpopulations of MVs were not different between groups. M65 and M30 both had an area under the receiver operating characteristics curve of 0.84 to estimate the presence of AH. For M65, a cutoff of 2000 IU\/L had a positive predictive value of 91%, whereas a cutoff of 641 IU\/L had a negative predictive value of 88%. In the validation cohort, AH was histologically confirmed in 48 of 68 (71%)\u00a0<span class=\"highlight\">patients<\/span>. ABIC score was B or C in 69% of\u00a0<span class=\"highlight\">patients<\/span>. For M65, the above cutoffs had a diagnostic accuracy of 81%. Even better results were obtained in\u00a0<span class=\"highlight\">patients<\/span>\u00a0with suspicion of severe AH (ABIC B or C) in both cohorts.<\/p>\r\n<h4 style=\"text-align: justify;\">CONCLUSION:<\/h4>\r\n<p style=\"text-align: justify;\">Plasma\u00a0<span class=\"highlight\">levels<\/span>\u00a0of cytokeratin-18 fragments are reliable noninvasive markers of AH. Using the proposed cutoffs for M65, two thirds of TJLB can be avoided, which can be useful in centers where this technique is not readily available. (Hepatology 2017;66:555-563).<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis. - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/a-prospective-study-of-the-utility-of-plasma-biomarkers-to-diagnose-alcoholic-hepatitis\/\",\"name\":\"A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis. - 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