{"id":14979,"date":"2019-11-07T13:56:55","date_gmt":"2019-11-07T12:56:55","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=14979"},"modified":"2025-09-11T16:48:02","modified_gmt":"2025-09-11T14:48:02","slug":"cd89-is-a-potent-innate-receptor-for-bacteria-and-mediates-host-protection-from-sepsis","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/cd89-is-a-potent-innate-receptor-for-bacteria-and-mediates-host-protection-from-sepsis\/","title":{"rendered":"CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-14979","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Cell Rep.","date_de_publication":"20190416","numero_doi":"","equipe":[138],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14975,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Heming N"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Correia MDT"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Abbad L"},{"texte_libre":false,"auteur-lien":13191,"auteur-text":""},{"texte_libre":false,"auteur-lien":13218,"auteur-text":""},{"texte_libre":false,"auteur-lien":13074,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bex J"},{"texte_libre":false,"auteur-lien":13038,"auteur-text":""},{"texte_libre":false,"auteur-lien":13179,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Soler-Torronteras R"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Denamur E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Galicier L"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Oksenhendler E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fehling HJ"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pinheiro da Silva F"},{"texte_libre":false,"auteur-lien":13030,"auteur-text":""},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":false,"auteur-lien":13033,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30995475"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c<sup>+<\/sup>\u00a0dendritic cells and monocytes and\/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In\u00a0vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/cd89-is-a-potent-innate-receptor-for-bacteria-and-mediates-host-protection-from-sepsis\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/cd89-is-a-potent-innate-receptor-for-bacteria-and-mediates-host-protection-from-sepsis\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/cd89-is-a-potent-innate-receptor-for-bacteria-and-mediates-host-protection-from-sepsis\/\",\"name\":\"CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. - 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