{"id":15742,"date":"2020-07-24T11:06:50","date_gmt":"2020-07-24T09:06:50","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=15742"},"modified":"2025-09-11T16:48:01","modified_gmt":"2025-09-11T14:48:01","slug":"ferroptosis-in-liver-diseases-an-overview","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/ferroptosis-in-liver-diseases-an-overview\/","title":{"rendered":"Ferroptosis in Liver Diseases: An Overview"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-15742","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Int J Mol Sci","date_de_publication":"20200711","numero_doi":"","equipe":[124],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Martina Maria Capelletti[:]"},{"texte_libre":false,"auteur-lien":13113,"auteur-text":""},{"texte_libre":false,"auteur-lien":13142,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Katell Peoc'h[:]"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32664576\/"}],"paragraphe":"[:fr]<p style=\"text-align: justify;\">La ferroptose est une forme de mort cellulaire d\u00e9pendante du fer, caract\u00e9ris\u00e9e par l\u2019accumulation intracellulaire de peroxydes lipidiques et un d\u00e9s\u00e9quilibre de l\u2019hom\u00e9ostasie r\u00e9dox. La ferroptose pr\u00e9sente des caract\u00e9ristiques biologiques et morphologiques sp\u00e9cifiques par rapport aux autres morts cellulaires, que sont notamment l\u2019apoptose et la n\u00e9crose. La perte de protection contre la peroxydation lipidique par la glutathion peroxydase 4 (GPX4), la pr\u00e9sence de fer redox-actif et l'oxydation des phospholipides contenant des acides gras polyinsatur\u00e9s (PUFA) sont consid\u00e9r\u00e9es comme les caract\u00e9ristiques paradigmatiques de la ferroptose. Plusieurs voies et acteurs mol\u00e9culaires, dont le m\u00e9tabolisme des acides amin\u00e9s et du fer, la ferritinophagie, l'adh\u00e9sion cellulaire, les voies p53, Keap1 \/ Nrf2 et la biosynth\u00e8se des phospholipides, peuvent modifier la sensibilit\u00e9 des cellules \u00e0 la ferroptose. Au fil des d\u00e9cennies,\u00a0la ferroptose a \u00e9t\u00e9 associ\u00e9e \u00e0 diverses maladies, dont l\u2019insuffisance r\u00e9nale aigu\u00eb, certains cancers, les l\u00e9sions d'isch\u00e9mie-reperfusion, ou les maladies cardiovasculaires, neurod\u00e9g\u00e9n\u00e9ratives et h\u00e9patiques. Dans cette revue, nous pr\u00e9sentons une analyse compl\u00e8te des principaux m\u00e9canismes biologiques et biochimiques de\u00a0cette forme de mort cellulaire ainsi qu\u2019un\u00a0aper\u00e7u des principales substances pharmacologiques utilis\u00e9es comme inducteurs et inhibiteurs. Nous rapportons ensuite la contribution de la ferroptose au spectre des maladies h\u00e9patiques, aigu\u00ebs ou chroniques. Enfin, nous discutons de l'utilisation de la ferroptose comme approche th\u00e9rapeutique dans le carcinome h\u00e9patocellulaire.<\/p>[:]","paragraphe_en":"[:en]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis. Several pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion, p53, Keap1\/Nrf2 and phospholipid biosynthesis, can modify susceptibility to ferroptosis. Through the decades, various diseases, including acute kidney injury; cancer; ischemia-reperfusion injury; and cardiovascular, neurodegenerative and hepatic disorders, have been associated with ferroptosis. In this review, we provide a comprehensive analysis of the main biological and biochemical mechanisms of ferroptosis and an overview of chemicals used as inducers and inhibitors. Then, we report the contribution of ferroptosis to the spectrum of liver diseases, acute or chronic. Finally, we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most common form of primary liver cancer.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ferroptosis in Liver Diseases: An Overview - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ferroptosis in Liver Diseases: An Overview - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/\",\"name\":\"Ferroptosis in Liver Diseases: An Overview - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\"},\"datePublished\":\"2020-07-24T09:06:50+00:00\",\"dateModified\":\"2025-09-11T14:48:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Ferroptosis in Liver Diseases: An Overview\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ferroptosis in Liver Diseases: An Overview - CRI","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Ferroptosis in Liver Diseases: An Overview - CRI","og_url":"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","article_modified_time":"2025-09-11T14:48:01+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/","url":"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/","name":"Ferroptosis in Liver Diseases: An Overview - CRI","isPartOf":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#website"},"datePublished":"2020-07-24T09:06:50+00:00","dateModified":"2025-09-11T14:48:01+00:00","breadcrumb":{"@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/ferroptosis-in-liver-diseases-an-overview\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.mlcom-dev.net\/publications\/"},{"@type":"ListItem","position":3,"name":"Ferroptosis in Liver Diseases: An Overview"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.mlcom-dev.net\/#website","url":"https:\/\/cri1149.mlcom-dev.net\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.mlcom-dev.net\/#organization","name":"CRI1149","url":"https:\/\/cri1149.mlcom-dev.net\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"post_type":"publication","author_name":"","_links":{"self":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication\/15742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/media?parent=15742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}