{"id":15790,"date":"2020-07-28T15:30:31","date_gmt":"2020-07-28T13:30:31","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=15790"},"modified":"2025-09-11T16:48:01","modified_gmt":"2025-09-11T14:48:01","slug":"short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition\/","title":{"rendered":"Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-15790","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Annu Rev Nutr.","date_de_publication":"20200706","numero_doi":"","equipe":[131],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13100,"auteur-text":""},{"texte_libre":false,"auteur-lien":14859,"auteur-text":""},{"texte_libre":false,"auteur-lien":13025,"auteur-text":""},{"texte_libre":false,"auteur-lien":13091,"auteur-text":""},{"texte_libre":false,"auteur-lien":13105,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev-nutr-011720-122203"}],"paragraphe":"[:fr]<p style=\"text-align: justify;\">Le syndrome du gr\u00eale court (SGC) est une maladie rare qui r\u00e9sulte d'une r\u00e9section chirurgicale extensive de l'intestin. Lorsque la surface d'absorption restante ne peut absorber suffisamment de macronutriments, de micronutriments et d'eau, le SGC entra\u00eene une insuffisance\u00a0 intestinale. En cons\u00e9quence, les patients atteints de SGC qui souffrent d\u2019insuffisance\u00a0 intestinale ont besoin d'une nutrition parent\u00e9rale pour survivre, mais \u00e0 long terme celle-ci peut \u00e0 son tour entra\u00eener des complications comme des septic\u00e9mies ou thromboses au niveau du cath\u00e9ter et des maladies m\u00e9taboliques h\u00e9patiques, une insuffisance r\u00e9nale ou des lithiases oxaliques.<\/p>\r\n<p style=\"text-align: justify;\">Apr\u00e8s la r\u00e9section, une adaptation intestinale spontan\u00e9e se produit dans les semaines ou mois qui suivent l\u2019intervention, entra\u00eenant une hyperplasie de l'intestin restant, une modification de l\u2019expression et de la s\u00e9cr\u00e9tion des hormones intestinales, une dysbiose (modification du microbiote) et une hyperphagie. La nutrition orale et la pr\u00e9sence du c\u00f4lon sont deux facteurs positifs majeurs de cette adaptation.<\/p>\r\n<p style=\"text-align: justify;\">Cette revue r\u00e9sume nos connaissances actuelles des m\u00e9canismes qui sous-tendent l'adaptation intestinale spontan\u00e9e, en particulier en r\u00e9ponse aux nutriments donn\u00e9s par voir orale aux patients afin d\u2019envisager\u00a0 \u00e0\u00a0 l'avenir, des manipulations alimentaires pour traiter l\u2019insuffisance\u00a0 intestinale li\u00e9e au SGC.<\/p>\r\n<p><img class=\"wp-image-15738 aligncenter\" src=\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2020\/07\/figure-maude-article-300x193.png\" alt=\"\" width=\"542\" height=\"349\" \/><\/p>\r\n<p><strong>\u00a0Figure\u00a0: Les trois sous-types de montage anatomique \u00e0 l\u2019origine du syndrome de gr\u00eale court.<\/strong><\/p>\r\n<ol>\r\n\t<li>R\u00e9section de l'intestin gr\u00eale avec j\u00e9junostomie<\/li>\r\n\t<li>R\u00e9section de l'intestin gr\u00eale avec ablation de l'il\u00e9on, de la valve il\u00e9o-c\u00e6cale et d'une partie du c\u00f4lon, ce qui entra\u00eene une anastomose j\u00e9junocolique.<\/li>\r\n\t<li>R\u00e9section de l'intestin gr\u00eale avec pr\u00e9servation d'une partie de l'il\u00e9on et de la valve il\u00e9o-c\u00e6cale et du c\u00f4lon, entra\u00eenant une anastomose j\u00e9juno-il\u00e9ale.<\/li>\r\n<\/ol>[:]","paragraphe_en":"[:en]<p style=\"text-align: justify;\">Short bowel syndrome (SBS) is a rare disease that results from extensive \u00a0resection of the intestine. When the remaining absorption surface of the intestine cannot absorb enough macronutrients, micronutrients, and water, SBS results in intestinal failure. Patients with SBS who suffer from intestinal failure require parenteral nutrition for survival, but long-term parenteral nutrition may also lead to complications such as catheter sepsis or thrombosis and metabolic liver diseases, renal failure and oxalic lithiasis.<\/p>\r\n<p style=\"text-align: justify;\">Spontaneous intestinal adaptation occurs weeks to months after resection,resulting in hyperplasia of the remnant gut, modification of gut hormone levels, dysbiosis (i.e;. modification of the intestinal microbiota), and hyperphagia. Oral nutrition and presence of the colon are two major positive drivers for this adaptation.<\/p>\r\n<p style=\"text-align: justify;\">This review aims to summarize the current knowledge of the mechanisms underlying spontaneous intestinal adaptation, particularly in response to modifications of luminal content, including nutrients. In the future, dietary manipulations could be used to treat SBS<\/p>\r\n<p><img class=\"alignnone  wp-image-15738\" src=\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2020\/07\/figure-maude-article-300x193.png\" alt=\"\" width=\"560\" height=\"360\" \/><\/p>\r\n<p><strong>Figure : Three anatomical subtypes of short bowel syndrome. <\/strong><\/p>\r\n<ol>\r\n\t<li>Small bowel resection with jejunostomy.<\/li>\r\n\t<li>Small bowel resection with removal of ileum, ileocecal valve, and part of the colon, resulting in jejunocolic anastomosis.<\/li>\r\n\t<li>Small bowel resection in which some ileum is preserved and the ileocecal valve and colon remain intact, resulting in jejunoileal anastomosis<\/li>\r\n<\/ol>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition? - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition? 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