{"id":16016,"date":"2020-10-12T10:01:08","date_gmt":"2020-10-12T08:01:08","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&p=16016"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"emergence-of-kawasaki-disease-related-to-sars-cov-2-infection-in-an-epicentre-of-the-french-covid-19-epidemic-a-time-series-analysis","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/emergence-of-kawasaki-disease-related-to-sars-cov-2-infection-in-an-epicentre-of-the-french-covid-19-epidemic-a-time-series-analysis\/","title":{"rendered":"Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-16016","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Lancet Child Adolesc Health.","date_de_publication":"20200901","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Naim Ouldali[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Marie Pouletty[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Patricia Mariani[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Constance Beyler[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Audrey Blachier[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Stephane Bonacorsi[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Kostas Danis[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Maryline Chomton[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Laure Maurice[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Fleur Le Bourgeois[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marion Caseris[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Jean Gaschignard[:]"},{"texte_libre":false,"auteur-lien":14587,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Robert Cohen[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Luigi Titomanlio[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Albert Faye[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Isabelle Melki[:]"},{"texte_libre":false,"auteur-lien":13118,"auteur-text":[]}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7332278\/"}],"paragraphe":"[:fr]

R\u00e9sum\u00e9<\/h2>\r\n
\r\n
\r\n

Contexte<\/h3>\r\n

La maladie de Kawasaki est une vascularite infantile f\u00e9brile syst\u00e9mique aigu\u00eb, qui est suspect\u00e9e d'\u00eatre d\u00e9clench\u00e9e par des infections virales respiratoires.\u00a0Nous visions \u00e0 examiner si l'\u00e9pid\u00e9mie de COVID-19 en cours, caus\u00e9e par le coronavirus 2 du syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS-CoV-2), \u00e9tait associ\u00e9e \u00e0 une augmentation de l'incidence de la maladie de Kawasaki.<\/p>\r\n<\/div>\r\n

\r\n

M\u00e9thodes<\/h3>\r\n

Nous avons effectu\u00e9 une analyse quasi-exp\u00e9rimentale de s\u00e9ries chronologiques interrompues au cours des 15 derni\u00e8res ann\u00e9es dans un centre p\u00e9diatrique tertiaire de la r\u00e9gion parisienne, \u00e9picentre fran\u00e7ais de l'\u00e9pid\u00e9mie de COVID-19.\u00a0Le principal crit\u00e8re de jugement \u00e9tait le nombre de cas de maladie de Kawasaki au fil du temps, estim\u00e9 par r\u00e9gression quasi-Poisson.\u00a0Dans le m\u00eame centre, nous avons enregistr\u00e9 le nombre d'hospitalisations \u00e0 l'urgence (2005-2020) et les r\u00e9sultats de la PCR multiplex nasopharyng\u00e9e pour identifier les pathog\u00e8nes respiratoires (2017-2020).\u00a0Ces donn\u00e9es ont \u00e9t\u00e9 compar\u00e9es aux hospitalisations journali\u00e8res dues \u00e0 un COVID-19 confirm\u00e9 dans la m\u00eame r\u00e9gion, enregistr\u00e9es par Sant\u00e9 publique France.<\/p>\r\n<\/div>\r\n

\r\n

R\u00e9sultats<\/h3>\r\n

Entre le 1er d\u00e9cembre 2005 et le 20 mai 2020, nous avons inclus 230 patients atteints de la maladie de Kawasaki.\u00a0Le nombre m\u00e9dian d'hospitalisations pour maladie de Kawasaki estim\u00e9 par le mod\u00e8le quasi-Poisson \u00e9tait de 1 \u00b7 2 par mois (IQR 1 \u00b7 1\u20131 \u00b7 3).\u00a0En avril 2020, nous avons identifi\u00e9 une augmentation rapide de la maladie de Kawasaki li\u00e9e au SRAS-CoV-2 (six cas par mois; augmentation de 497% [IC \u00e0 95% 72\u20131082]; p = 0 \u00b7 0011), \u00e0 partir de 2 semaines apr\u00e8s le pic de l'\u00e9pid\u00e9mie de COVID-19.\u00a0Le SRAS-CoV-2 \u00e9tait le seul virus \u00e0 circuler intens\u00e9ment pendant cette p\u00e9riode, et a \u00e9t\u00e9 trouv\u00e9 chez huit (80%) des dix patients atteints de la maladie de Kawasaki depuis le 15 avril (PCR ou s\u00e9rologie SARS-CoV-2-positif).\u00a0Un deuxi\u00e8me pic d'hospitalisation en raison de la maladie de Kawasaki a \u00e9t\u00e9 observ\u00e9 en d\u00e9cembre 2009 (six cas par mois; augmentation de 365% ([31\u2013719]; p = 0,0053), concomitant \u00e0 la pand\u00e9mie de grippe A H1N1.<\/p>\r\n<\/div>\r\n

\r\n

Interpr\u00e9tation<\/h3>\r\n

Notre \u00e9tude sugg\u00e8re en outre que les infections respiratoires virales, y compris le SAR-CoV-2, pourraient \u00eatre des d\u00e9clencheurs de la maladie de Kawasaki et indique le moment potentiel d'une augmentation de l'incidence de la maladie dans les \u00e9pid\u00e9mies de COVID-19.\u00a0Les prestataires de soins de sant\u00e9 doivent \u00eatre pr\u00eats \u00e0 g\u00e9rer un afflux de patients atteints de la maladie grave de Kawasaki, en particulier dans les pays o\u00f9 le pic de COVID-19 a r\u00e9cemment \u00e9t\u00e9 atteint.<\/p>\r\n<\/div>\r\n<\/div>[:en]

R\u00e9sum\u00e9<\/span><\/h2>\r\n
\r\n
\r\n

Contexte<\/span><\/h3>\r\n

La maladie de Kawasaki est une vascularite infantile f\u00e9brile syst\u00e9mique aigu\u00eb, qui est suspect\u00e9e d'\u00eatre d\u00e9clench\u00e9e par des infections virales respiratoires.\u00a0Nous visions \u00e0 examiner si l'\u00e9pid\u00e9mie de COVID-19 en cours, caus\u00e9e par le coronavirus 2 du syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS-CoV-2), \u00e9tait associ\u00e9e \u00e0 une augmentation de l'incidence de la maladie de Kawasaki.<\/span><\/p>\r\n<\/div>\r\n

\r\n

M\u00e9thodes<\/span><\/h3>\r\n

Nous avons effectu\u00e9 une analyse quasi-exp\u00e9rimentale de s\u00e9ries chronologiques interrompues au cours des 15 derni\u00e8res ann\u00e9es dans un centre p\u00e9diatrique tertiaire de la r\u00e9gion parisienne, \u00e9picentre fran\u00e7ais de l'\u00e9pid\u00e9mie de COVID-19.\u00a0Le principal crit\u00e8re de jugement \u00e9tait le nombre de cas de maladie de Kawasaki au fil du temps, estim\u00e9 par r\u00e9gression quasi-Poisson.\u00a0Dans le m\u00eame centre, nous avons enregistr\u00e9 le nombre d'hospitalisations \u00e0 l'urgence (2005-2020) et les r\u00e9sultats de la PCR multiplex nasopharyng\u00e9e pour identifier les pathog\u00e8nes respiratoires (2017-2020).\u00a0Ces donn\u00e9es ont \u00e9t\u00e9 compar\u00e9es aux hospitalisations journali\u00e8res dues \u00e0 un COVID-19 confirm\u00e9 dans la m\u00eame r\u00e9gion, enregistr\u00e9es par Sant\u00e9 publique France.<\/span><\/p>\r\n<\/div>\r\n

\r\n

R\u00e9sultats<\/span><\/h3>\r\n

Entre le 1er d\u00e9cembre 2005 et le 20 mai 2020, nous avons inclus 230 patients atteints de la maladie de Kawasaki.\u00a0Le nombre m\u00e9dian d'hospitalisations pour maladie de Kawasaki estim\u00e9 par le mod\u00e8le quasi-Poisson \u00e9tait de 1 \u00b7 2 par mois (IQR 1 \u00b7 1\u20131 \u00b7 3).\u00a0En avril 2020, nous avons identifi\u00e9 une augmentation rapide de la maladie de Kawasaki li\u00e9e au SRAS-CoV-2 (six cas par mois; augmentation de 497% [IC \u00e0 95% 72\u20131082]; p = 0 \u00b7 0011), \u00e0 partir de 2 semaines apr\u00e8s le pic de l'\u00e9pid\u00e9mie de COVID-19.\u00a0Le SRAS-CoV-2 \u00e9tait le seul virus \u00e0 circuler intens\u00e9ment pendant cette p\u00e9riode, et a \u00e9t\u00e9 trouv\u00e9 chez huit (80%) des dix patients atteints de la maladie de Kawasaki depuis le 15 avril (PCR ou s\u00e9rologie SARS-CoV-2-positif).\u00a0Un deuxi\u00e8me pic d'hospitalisation en raison de la maladie de Kawasaki a \u00e9t\u00e9 observ\u00e9 en d\u00e9cembre 2009 (six cas par mois; augmentation de 365% ([31\u2013719]; p = 0,0053), concomitant \u00e0 la pand\u00e9mie de grippe A H1N1.<\/span><\/p>\r\n<\/div>\r\n

\r\n

Interpr\u00e9tation<\/span><\/h3>\r\n

Notre \u00e9tude sugg\u00e8re en outre que les infections respiratoires virales, y compris le SAR-CoV-2, pourraient \u00eatre des d\u00e9clencheurs de la maladie de Kawasaki et indique le moment potentiel d'une augmentation de l'incidence de la maladie dans les \u00e9pid\u00e9mies de COVID-19.\u00a0Les prestataires de soins de sant\u00e9 doivent \u00eatre pr\u00eats \u00e0 g\u00e9rer un afflux de patients atteints de la maladie grave de Kawasaki, en particulier dans les pays o\u00f9 le pic de COVID-19 a r\u00e9cemment \u00e9t\u00e9 atteint.<\/span><\/p>\r\n<\/div>\r\n<\/div>[:]","paragraphe_en":"","documents":null},"yoast_head":"\nEmergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis - 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