{"id":16401,"date":"2021-01-19T11:08:39","date_gmt":"2021-01-19T10:08:39","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=16401"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"liver-stiffness-by-transient-elastography-to-detect-porto-sinusoidal-vascular-liver-disease-with-portal-hypertension","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/liver-stiffness-by-transient-elastography-to-detect-porto-sinusoidal-vascular-liver-disease-with-portal-hypertension\/","title":{"rendered":"Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-16401","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Hepatology","date_de_publication":"20201221","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14888,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marie Lazareth[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Sylvie Chevret[:]"},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marta Magaz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Lorraine Blaise[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Laura Rubbia-Brandt[:]"},{"texte_libre":false,"auteur-lien":13258,"auteur-text":""},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Audrey Payanc\u00e9[:]"},{"texte_libre":false,"auteur-lien":14887,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Cendrine Chaffaut[:]"},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marion Malphettes[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Alba Diaz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Jean-Charles Nault[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Pierre Nahon[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Etienne Audureau[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Vlad Ratziu[:]"},{"texte_libre":false,"auteur-lien":13047,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Juan-Carlos Garcia Pagan[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Nathalie Ganne-Carrie[:]"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]ANRS CO12 CirVir group[:]"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/33345307\/"}],"paragraphe":"[:en]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Background &amp; aims:\u00a0<\/strong>Porto-sinusoidal vascular liver disease (PSVD) is a rare cause of portal hypertension. PSVD is still often misdiagnosed as cirrhosis, emphasizing the need to improve PSVD diagnosis strategies. Data on liver stiffness measurement (TE-LSM) using transient elastography, in PSVD are limited. The aim of this study was to evaluate the accuracy of TE-LSM to discriminate PSVD from cirrhosis in patients with signs of portal hypertension.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Approach &amp; results:\u00a0<\/strong>Retrospective multicenter study comparing TE-LSM in patients with PSVD, according to VALDIG criteria, to patients with compensated biopsy-proven cirrhosis related to alcohol (n=117), hepatitis C virus (HCV) infection (n=110) or non-alcoholic fatty liver disease (NAFLD) (n=46). All patients had at least one sign of portal hypertension among gastroesophageal varices, splenomegaly, porto-systemic collaterals, history of ascites or platelet count &lt; 150 x 10<sup>9<\/sup>\u00a0\/L. The 77 patients with PSVD included in the test cohort had lower median TE-LSM [7.9 kilopascals (kPa)] than the patients with alcohol-, HCV- and NAFLD-related cirrhosis (33.8 kPa, 18.2 kPa, and 33.6 kPa, respectively; p&lt;0.001). When compared to cirrhosis, a cut-off value of 10 kPa had a specificity of 97% for the diagnosis of PSVD, with a 85% positive predictive value. A cut-off value of 20 kPa had a sensitivity of 94% for ruling-out PSVD, with a 97% negative predictive value. 94% of the patients were well-classified. Even better results were obtained in a validation cohort including 78 PSVD patients.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This study including a total of 155 patients with PSVD and 273 patients with cirrhosis demonstrates that TE-LSM &lt;10 kPa strongly suggests PSVD in patients with signs of portal hypertension. Conversely, when TE-LSM is &gt;20 kPa, PSVD is highly unlikely.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:en]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Background &amp; aims:\u00a0<\/strong>Porto-sinusoidal vascular liver disease (PSVD) is a rare cause of portal hypertension. PSVD is still often misdiagnosed as cirrhosis, emphasizing the need to improve PSVD diagnosis strategies. Data on liver stiffness measurement (TE-LSM) using transient elastography, in PSVD are limited. The aim of this study was to evaluate the accuracy of TE-LSM to discriminate PSVD from cirrhosis in patients with signs of portal hypertension.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Approach &amp; results:\u00a0<\/strong>Retrospective multicenter study comparing TE-LSM in patients with PSVD, according to VALDIG criteria, to patients with compensated biopsy-proven cirrhosis related to alcohol (n=117), hepatitis C virus (HCV) infection (n=110) or non-alcoholic fatty liver disease (NAFLD) (n=46). All patients had at least one sign of portal hypertension among gastroesophageal varices, splenomegaly, porto-systemic collaterals, history of ascites or platelet count &lt; 150 x 10<sup>9<\/sup>\u00a0\/L. The 77 patients with PSVD included in the test cohort had lower median TE-LSM [7.9 kilopascals (kPa)] than the patients with alcohol-, HCV- and NAFLD-related cirrhosis (33.8 kPa, 18.2 kPa, and 33.6 kPa, respectively; p&lt;0.001). When compared to cirrhosis, a cut-off value of 10 kPa had a specificity of 97% for the diagnosis of PSVD, with a 85% positive predictive value. A cut-off value of 20 kPa had a sensitivity of 94% for ruling-out PSVD, with a 97% negative predictive value. 94% of the patients were well-classified. Even better results were obtained in a validation cohort including 78 PSVD patients.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This study including a total of 155 patients with PSVD and 273 patients with cirrhosis demonstrates that TE-LSM &lt;10 kPa strongly suggests PSVD in patients with signs of portal hypertension. Conversely, when TE-LSM is &gt;20 kPa, PSVD is highly unlikely.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/liver-stiffness-by-transient-elastography-to-detect-porto-sinusoidal-vascular-liver-disease-with-portal-hypertension\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:00+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/liver-stiffness-by-transient-elastography-to-detect-porto-sinusoidal-vascular-liver-disease-with-portal-hypertension\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/liver-stiffness-by-transient-elastography-to-detect-porto-sinusoidal-vascular-liver-disease-with-portal-hypertension\/\",\"name\":\"Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension - 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