{"id":43800,"date":"2021-11-05T15:01:41","date_gmt":"2021-11-05T14:01:41","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=43800"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"is-complement-the-main-accomplice-in-iga-nephropathy-from-initial-observations-to-potential-complement-targeted-therapies","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/is-complement-the-main-accomplice-in-iga-nephropathy-from-initial-observations-to-potential-complement-targeted-therapies\/","title":{"rendered":"Is complement the main accomplice in IgA nephropathy? From initial observations to potential complement-targeted therapies"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-43800","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"[:en]Mol Immunol.[:]","date_de_publication":"20210930","numero_doi":"","equipe":[138],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13218,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Patrick J Gleeson[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Mohamed R Daha[:]"},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]C van Kooten[:]"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/34601376\/"}],"paragraphe":"[:fr]<p style=\"text-align: justify;\">R\u00e9sum\u00e9<br \/>\r\nLa n\u00e9phropathie \u00e0 IgA (IgAN) est la principale cause de glom\u00e9rulon\u00e9phrite primitive dans le monde. Cette maladie est associ\u00e9e \u00e0 un large \u00e9ventail de pr\u00e9sentations cliniques, \u00e0 un pronostic variable et \u00e0 un \u00e9ventail de r\u00e9sultats histologiques. Plus de cinquante ans apr\u00e8s sa premi\u00e8re description, cette h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 continue de compliquer les efforts pour comprendre la pathogen\u00e8se. N\u00e9anmoins, l'implication du syst\u00e8me du compl\u00e9ment dans l'IgAN a \u00e9t\u00e9 identifi\u00e9e tr\u00e8s t\u00f4t. Le dysfonctionnement du syst\u00e8me d'immunoglobuline A (IgA), principal responsable de cette maladie, y compris la modification des isoformes et des glycoformes d'IgA1, la nature des complexes immuns et des auto-anticorps dirig\u00e9s contre l'IgA1 d\u00e9ficiente en galactose pourraient tous \u00eatre responsables de l'activation du compl\u00e9ment dans l'IgAN. Cependant, les m\u00e9canismes sp\u00e9cifiques engageant le compl\u00e9ment sont encore \u00e0 l'\u00e9tude. La recherche dans ce domaine devrait permettre d'identifier les patients qui pourraient b\u00e9n\u00e9ficier d'une th\u00e9rapie cibl\u00e9e sur le compl\u00e9ment, dans un avenir pr\u00e9visible.<\/p>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">IgA Nephropathy (IgAN) is the main cause of primary glomerulonephritis, globally. This disease is associated with a wide range of clinical presentations, variable prognosis and a spectrum of histological findings. More than fifty years after its first description, this heterogeneity continues to complicate efforts to understand the pathogenesis. Nevertheless, involvement of the complement system in IgAN was identified early on. Dysfunction of the immunoglobulin A (IgA) system, the principal offender in this disease, including modification of isoforms and glycoforms of IgA1, the nature of immune complexes and autoantibodies to galactose deficient IgA1 might all be responsible for complement activation in IgAN. However, the specific mechanisms engaging complement are still under examination. Research in this domain should allow for identification of patients that may benefit from complement-targeted therapy, in the foreseeable future.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is complement the main accomplice in IgA nephropathy? 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