{"id":53758,"date":"2022-02-10T16:03:47","date_gmt":"2022-02-10T15:03:47","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=53758"},"modified":"2025-09-11T16:47:59","modified_gmt":"2025-09-11T14:47:59","slug":"contrast-enhanced-ct-and-liver-surface-nodularity-for-the-diagnosis-of-porto-sinusoidal-vascular-disorder-a-case-control-study","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/contrast-enhanced-ct-and-liver-surface-nodularity-for-the-diagnosis-of-porto-sinusoidal-vascular-disorder-a-case-control-study\/","title":{"rendered":"Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-53758","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Hepatology.","date_de_publication":"20220129","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Shantha Ram Valainathan[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Riccardo Sartoris[:]"},{"texte_libre":false,"auteur-lien":14888,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marta Magaz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Fabian Betancourt[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Silvia Pellegrino[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Arianna Nivolli[:]"},{"texte_libre":false,"auteur-lien":14728,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Yves Flattet[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Sylvain Terraz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Nicolas Drilhon[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marie Lazareth[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Julia Herrou[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Onorina Bruno[:]"},{"texte_libre":true,"auteur-lien":"","auteur-text":"[:fr]Audrey Payance [:]"},{"texte_libre":false,"auteur-lien":14887,"auteur-text":""},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":false,"auteur-lien":13148,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Juan Carlos Garcia-Pagan[:]"},{"texte_libre":false,"auteur-lien":13166,"auteur-text":""},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/35092315\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Background and aims:\u00a0<\/strong>Porto-sinusoidal vascular disorder (PSVD) is a rare and commonly overlooked cause of portal hypertension. The interest of computerized tomography (CT) analysis, including quantification of liver surface nodularity (LSN) for PSVD diagnosis has not been established. This study aimed at assessing the performance of LSN and CT features for a PSVD diagnosis in patients with signs of portal hypertension.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Approach and results:\u00a0<\/strong>This retrospective case-control study included a learning cohort consisting in 50 patients with histologically proven PSVD, according to VALDIG criteria, and 100 control patients with histologically proven cirrhosis, matched on ascites. All patients and controls had at least one sign of portal hypertension and CT available within one year from liver biopsy. Principal component analysis of CT features separated patients with PSVD from patients with cirrhosis. Patients with PSVD had lower median LSN than those with cirrhosis (2.4 vs. 3.1, p&lt;0.001). Multivariate analysis identified LSN &lt; 2.5 and normal-sized or enlarged segment IV as independently associated with PSVD. Combination of these 2 features had a specificity of 90% for PSVD and a diagnostic accuracy of 84%. Even better results were obtained in an independent multicenter validation cohort including 53 patients with PSVD and 106 control patients with cirrhosis (specificity 94%, diagnostic accuracy 87%).<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This study including a total of 103 patients with PSVD and 206 patients with cirrhosis demonstrates that LSN &lt; 2.5 combined with normal-sized or enlarged segment IV strongly suggests PSVD in patients with signs of portal hypertension.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Background and aims:\u00a0<\/strong>Porto-sinusoidal vascular disorder (PSVD) is a rare and commonly overlooked cause of portal hypertension. The interest of computerized tomography (CT) analysis, including quantification of liver surface nodularity (LSN) for PSVD diagnosis has not been established. This study aimed at assessing the performance of LSN and CT features for a PSVD diagnosis in patients with signs of portal hypertension.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Approach and results:\u00a0<\/strong>This retrospective case-control study included a learning cohort consisting in 50 patients with histologically proven PSVD, according to VALDIG criteria, and 100 control patients with histologically proven cirrhosis, matched on ascites. All patients and controls had at least one sign of portal hypertension and CT available within one year from liver biopsy. Principal component analysis of CT features separated patients with PSVD from patients with cirrhosis. Patients with PSVD had lower median LSN than those with cirrhosis (2.4 vs. 3.1, p&lt;0.001). Multivariate analysis identified LSN &lt; 2.5 and normal-sized or enlarged segment IV as independently associated with PSVD. Combination of these 2 features had a specificity of 90% for PSVD and a diagnostic accuracy of 84%. Even better results were obtained in an independent multicenter validation cohort including 53 patients with PSVD and 106 control patients with cirrhosis (specificity 94%, diagnostic accuracy 87%).<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This study including a total of 103 patients with PSVD and 206 patients with cirrhosis demonstrates that LSN &lt; 2.5 combined with normal-sized or enlarged segment IV strongly suggests PSVD in patients with signs of portal hypertension.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study - 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