{"id":65319,"date":"2023-03-09T12:24:02","date_gmt":"2023-03-09T11:24:02","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=65319"},"modified":"2025-09-11T16:47:58","modified_gmt":"2025-09-11T14:47:58","slug":"basophils-and-ige-in-autoimmunity-mechanisms-and-therapeutic-targets","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/basophils-and-ige-in-autoimmunity-mechanisms-and-therapeutic-targets\/","title":{"rendered":"Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-65319","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Med Sci (Paris).","date_de_publication":"20220401","numero_doi":"","equipe":[101],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13209,"auteur-text":""},{"texte_libre":false,"auteur-lien":13051,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/35485897\/"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract\u00a0<\/h2>\r\n<div id=\"fra-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Title:\u00a0<\/strong>Les granulocytes basophiles et les IgE dans l\u2019autoimmunit\u00e9 - M\u00e9canismes et cibles th\u00e9rapeutiques.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Abstract:\u00a0<\/strong>Comprendre les m\u00e9canismes physiopathologiques des maladies autoimmunes pr\u00e9sentant des auto-anticorps (MAPA) repr\u00e9sente un enjeu majeur pour le d\u00e9veloppement d\u2019approches th\u00e9rapeutiques innovantes. Sans en conna\u00eetre pr\u00e9cis\u00e9ment les origines, chez certains individus, la perte de tol\u00e9rance \u00e0 des antig\u00e8nes du soi conduit \u00e0 l\u2019instauration d\u2019une r\u00e9action en cha\u00eene autoimmune. Des autoanticorps sont cependant pr\u00e9sents dans une large proportion de la population g\u00e9n\u00e9rale sans \u00eatre associ\u00e9s \u00e0 une maladie. L\u2019amplification de la production de ces autoanticorps, la formation de complexes immuns circulants et l\u2019activation du syst\u00e8me immunitaire inn\u00e9 menant \u00e0 cette amplification sont des processus centraux dans la pathog\u00e9nie des maladies auto-immunes. Dans cette revue, nous pr\u00e9sentons la contribution de l\u2019immunit\u00e9 de type 2, des granulocytes basophiles et des IgE, dans l\u2019instauration de boucles d\u2019amplification pathog\u00e9niques dans les MAPA, en particulier dans le lupus \u00e9ryth\u00e9mateux diss\u00e9min\u00e9 et la connectivite mixte.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract\u00a0<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Understanding the pathophysiology of antibody-driven autoimmune diseases (AAID) represents a major challenge for the biomedical community to develop innovative therapeutic strategies that are still lacking to control these diseases. If the reason why AAID are developing still needs to be defined, loss of tolerance to self-antigens leads to the development of an autoimmune chain reaction in some individuals. However, autoreactive antibodies are present in a large proportion of the general population without any associated pathological condition. The amplification of autoantibody production, circulating immune complex formation and innate immune system activation leading to this amplification are some central phenomena in AAID pathophysiology. In this review, we summarize the contribution of type 2 immunity, basophils and IgE in the initiation of some amplification loops that are pathogenic in some AAID, including systemic lupus erythematosus and mixed connective tissue disease.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/basophils-and-ige-in-autoimmunity-mechanisms-and-therapeutic-targets\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:47:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/basophils-and-ige-in-autoimmunity-mechanisms-and-therapeutic-targets\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/basophils-and-ige-in-autoimmunity-mechanisms-and-therapeutic-targets\/\",\"name\":\"Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets - 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