{"id":65329,"date":"2023-03-09T13:16:58","date_gmt":"2023-03-09T12:16:58","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=65329"},"modified":"2025-09-11T16:47:57","modified_gmt":"2025-09-11T14:47:57","slug":"the-high-affinity-ige-receptor-a-signaling-update","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/the-high-affinity-ige-receptor-a-signaling-update\/","title":{"rendered":"The high affinity IgE receptor: a signaling update"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-65329","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Curr Opin Immunol.","date_de_publication":"20211001","numero_doi":"","equipe":[101],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13037,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Hua Huang"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Toshiaki Kawakami"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/33838574\/"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Here we update receptor proximal and distant signaling events of the mast cell high affinity IgE receptor (Fc\u03b5RI) launching immediate type I hypersensitivity and an inflammatory cytokine-chemokine cascade. Different physiologic antigen concentrations, their affinity, and valency for the IgE ligand produce distinct intracellular signaling events with different outcomes. Investigating mast cell degranulation has revealed a complex molecular machinery that relays proximal signaling to cytoskeletal reorganization, granule transport and membrane fusion. Several new phosphorylation- and calcium-responsive effectors have been described. Fc\u03b5RI signaling also promotes de novo gene transcription. Recent progress has identified enhancers at genes that are upregulated in mast cells after stimulation through Fc\u03b5RI using next generation sequencing methods. Enhancers at genes that respond to antigenic stimulation in human mast cells revealed Ca<sup>2+<\/sup>-dependency. Stimulation-responsive super enhancers in mouse mast cells have also been identified. Mast cell lineage-determining transcription factor GATA2 primes these enhancers to respond to antigenic stimulation.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Here we update receptor proximal and distant signaling events of the mast cell high affinity IgE receptor (Fc\u03b5RI) launching immediate type I hypersensitivity and an inflammatory cytokine-chemokine cascade. Different physiologic antigen concentrations, their affinity, and valency for the IgE ligand produce distinct intracellular signaling events with different outcomes. Investigating mast cell degranulation has revealed a complex molecular machinery that relays proximal signaling to cytoskeletal reorganization, granule transport and membrane fusion. Several new phosphorylation- and calcium-responsive effectors have been described. Fc\u03b5RI signaling also promotes de novo gene transcription. Recent progress has identified enhancers at genes that are upregulated in mast cells after stimulation through Fc\u03b5RI using next generation sequencing methods. Enhancers at genes that respond to antigenic stimulation in human mast cells revealed Ca<sup>2+<\/sup>-dependency. Stimulation-responsive super enhancers in mouse mast cells have also been identified. Mast cell lineage-determining transcription factor GATA2 primes these enhancers to respond to antigenic stimulation.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The high affinity IgE receptor: a signaling update - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The high affinity IgE receptor: a signaling update - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/the-high-affinity-ige-receptor-a-signaling-update\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:47:57+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/the-high-affinity-ige-receptor-a-signaling-update\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/the-high-affinity-ige-receptor-a-signaling-update\/\",\"name\":\"The high affinity IgE receptor: a signaling update - 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