{"id":65991,"date":"2023-04-13T15:44:16","date_gmt":"2023-04-13T13:44:16","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=65991"},"modified":"2025-09-11T16:47:57","modified_gmt":"2025-09-11T14:47:57","slug":"prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","title":{"rendered":"Prevalence of Yersinia Species in the Ileum of Crohn&#8217;s Disease Patients and Controls"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-65991","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Cell Infect Microbiol.","date_de_publication":"20180921","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guillaume Le Baut"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claire O'Brien"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Paul Pavli"},{"texte_libre":false,"auteur-lien":13149,"auteur-text":""},{"texte_libre":true,"auteur-lien":"","auteur-text":"Philippe Seksik"},{"texte_libre":false,"auteur-lien":13160,"auteur-text":""},{"texte_libre":true,"auteur-lien":"","auteur-text":"St\u00e9phane Nancey"},{"texte_libre":true,"auteur-lien":"","auteur-text":"Nicolas Barnich"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Madeleine Bezault"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claire Auzolle"},{"texte_libre":false,"auteur-lien":13049,"auteur-text":""},{"texte_libre":false,"auteur-lien":13164,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthieu Allez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"REMIND GROUP"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":false,"auteur-lien":13067,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6160741\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><i>Yersinia<\/i>\u00a0are common contaminants of food products, but their prevalence in the human gut is poorly documented.\u00a0<i>Yersinia<\/i>\u00a0have been implicated in Crohn's Disease (CD, an inflammatory bowel disease) however their role in CD is controversial. We performed highly sensitive PCR assays of specific sequences for the\u00a0<i>gyrB<\/i>\u00a0gene of\u00a0<i>Y. aldovae, Y. bercovieri, Y. enterocolitica, Y. intermedia, Y. mollaretii<\/i>\u00a0and the\u00a0<i>inv<\/i>\u00a0gene of\u00a0<i>Y. pseudotuberculosis<\/i>. We analyzed a total of 470 ileal samples taken from 338 participants (262 CD patients and 76 controls) belonging to three independent cohorts. All patients and controls were phenotyped and genotyped for the main CD susceptibility variants:\u00a0<i>NOD2, ATG16L1<\/i>, and\u00a0<i>IRGM<\/i>.\u00a0<i>Yersinia<\/i>\u00a0were found in 7.7% of ileal samples (respectively 7.9 and 7.6% in controls and CD patients) corresponding to 10% of participants (respectively 11.8 and 9.5% in controls and CD patients).\u00a0<i>Y. enterocolitica, Y. pseudotuberculosis<\/i>\u00a0and\u00a0<i>Y. intermedia<\/i>\u00a0were the most frequently identified species. The bacteria were more frequent in resected specimens, lymph nodes and Peyer's patches.\u00a0<i>Yersinia<\/i>\u00a0were no more likely to be detected in CD tissues than tissues from inflammatory and non-inflammatory controls. CD patients treated with immunosuppressants were less likely to be\u00a0<i>Yersinia<\/i>\u00a0carriers. In conclusion, this work shows that\u00a0<i>Yersinia<\/i>\u00a0species are frequently found at low levels in the human ileum in health and disease. The role of\u00a0<i>Yersinia<\/i>\u00a0species in this ecosystem should now be explored.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><i>Yersinia<\/i>\u00a0are common contaminants of food products, but their prevalence in the human gut is poorly documented.\u00a0<i>Yersinia<\/i>\u00a0have been implicated in Crohn's Disease (CD, an inflammatory bowel disease) however their role in CD is controversial. We performed highly sensitive PCR assays of specific sequences for the\u00a0<i>gyrB<\/i>\u00a0gene of\u00a0<i>Y. aldovae, Y. bercovieri, Y. enterocolitica, Y. intermedia, Y. mollaretii<\/i>\u00a0and the\u00a0<i>inv<\/i>\u00a0gene of\u00a0<i>Y. pseudotuberculosis<\/i>. We analyzed a total of 470 ileal samples taken from 338 participants (262 CD patients and 76 controls) belonging to three independent cohorts. All patients and controls were phenotyped and genotyped for the main CD susceptibility variants:\u00a0<i>NOD2, ATG16L1<\/i>, and\u00a0<i>IRGM<\/i>.\u00a0<i>Yersinia<\/i>\u00a0were found in 7.7% of ileal samples (respectively 7.9 and 7.6% in controls and CD patients) corresponding to 10% of participants (respectively 11.8 and 9.5% in controls and CD patients).\u00a0<i>Y. enterocolitica, Y. pseudotuberculosis<\/i>\u00a0and\u00a0<i>Y. intermedia<\/i>\u00a0were the most frequently identified species. The bacteria were more frequent in resected specimens, lymph nodes and Peyer's patches.\u00a0<i>Yersinia<\/i>\u00a0were no more likely to be detected in CD tissues than tissues from inflammatory and non-inflammatory controls. CD patients treated with immunosuppressants were less likely to be\u00a0<i>Yersinia<\/i>\u00a0carriers. In conclusion, this work shows that\u00a0<i>Yersinia<\/i>\u00a0species are frequently found at low levels in the human ileum in health and disease. The role of\u00a0<i>Yersinia<\/i>\u00a0species in this ecosystem should now be explored.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prevalence of Yersinia Species in the Ileum of Crohn&#039;s Disease Patients and Controls - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevalence of Yersinia Species in the Ileum of Crohn&#039;s Disease Patients and Controls - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:47:57+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\",\"name\":\"Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls - 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