{"id":67605,"date":"2023-06-30T16:12:47","date_gmt":"2023-06-30T14:12:47","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=67605"},"modified":"2025-09-11T16:47:57","modified_gmt":"2025-09-11T14:47:57","slug":"hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","title":{"rendered":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-67605","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Hepatol","date_de_publication":"20230609","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14888,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nathalie Ganne-Carri\u00e9"},{"texte_libre":false,"auteur-lien":13113,"auteur-text":""},{"texte_libre":false,"auteur-lien":13245,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Shantha Ram Valainathan"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alix Riescher-Tuczkiewicz"},{"texte_libre":false,"auteur-lien":13228,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nathalie Barget"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cendrine Chaffaut"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alexandre Louvet"},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marianne Ziol"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rikke B\u00e6k"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Malene M\u00f8ller J\u00f8rgensen"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guillaume Van Niel"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pierre-Michael Coly"},{"texte_libre":false,"auteur-lien":13254,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fanny Dujardin"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Katell Peoc'h"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thierry Poynard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sylvie Chevret"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"CIRRAL group"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37302582\/"}],"paragraphe":"<h2><img class=\" wp-image-67683 aligncenter\" src=\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2023\/06\/Laure-V3-1-300x240.png\" alt=\"\" width=\"738\" height=\"590\" \/><\/h2>\r\n<h2 class=\"x_x_title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"x_x_eng-abstract\" class=\"x_x_abstract-content x_x_selected\">\r\n<p class=\"\" style=\"text-align: justify;\">In patients with compensated alcohol-related cirrhosis, reliable prognostic biomarkers are lacking. Keratin-18 and hepatocyte-derived large extracellular vesicles (lEVs) concentrations reflect disease activity, but their ability to predict liver-related events is unknown.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Methods:\u00a0<\/strong>We measured plasma keratin-18 and hepatocyte lEVs concentrations in 500 patients with Child-Pugh class A alcohol-related cirrhosis. Ability of these hepatocyte-derived biomarkers, alone or combined with MELD and FibroTest, to predict liver-related events at 2 years was analyzed, taking into account the alcohol consumption at inclusion and during the follow-up.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Results:\u00a0<\/strong>Keratin-18 and hepatocyte lEVs concentrations increased with alcohol consumption. In patients without active alcohol consumption at enrollment (n=419), keratin-18 concentration predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both keratin-18 concentration &gt;285 U\/L and FibroTest &gt;0.74 had a 24% cumulative incidence of liver-related events at 2 years, versus 5% to 14% in other groups of patients. Similar results were obtained when combining keratin-18 concentration &gt;285 U\/L with MELD &gt;10. In patients with active alcohol consumption at enrollment (n=81), hepatocyte lEVs predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both hepatocyte lEVs concentration &gt;50 U\/L and FibroTest&gt;0.74 had a 62% cumulative incidence of liver-related events at 2 years, versus 8% to 13% in other groups of patients. Combining hepatocyte lEVs concentration &gt;50 U\/L with MELD &gt;10 had a lower discrimination ability. Similar results were obtained using as endpoint decompensation of cirrhosis defined according Baveno VII criteria.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Conclusion:\u00a0<\/strong>In patients with Child-Pugh class A alcohol-related cirrhosis, combining hepatocyte-derived biomarkers with FibroTest or MELD score identifies patients at high-risk of liver-related events, and could be used for risk stratification and patient selection in clinical trials. \u00a0 \u00a0\u00a0<\/p>\r\n<\/div>","paragraphe_en":"<h2><img class=\" wp-image-67683 aligncenter\" src=\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2023\/06\/Laure-V3-1-300x240.png\" alt=\"\" width=\"738\" height=\"590\" \/><\/h2>\r\n<h2 class=\"x_x_title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"x_x_eng-abstract\" class=\"x_x_abstract-content x_x_selected\">\r\n<p class=\"\" style=\"text-align: justify;\">In patients with compensated alcohol-related cirrhosis, reliable prognostic biomarkers are lacking. Keratin-18 and hepatocyte-derived large extracellular vesicles (lEVs) concentrations reflect disease activity, but their ability to predict liver-related events is unknown.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Methods:\u00a0<\/strong>We measured plasma keratin-18 and hepatocyte lEVs concentrations in 500 patients with Child-Pugh class A alcohol-related cirrhosis. Ability of these hepatocyte-derived biomarkers, alone or combined with MELD and FibroTest, to predict liver-related events at 2 years was analyzed, taking into account the alcohol consumption at inclusion and during the follow-up.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Results:\u00a0<\/strong>Keratin-18 and hepatocyte lEVs concentrations increased with alcohol consumption. In patients without active alcohol consumption at enrollment (n=419), keratin-18 concentration predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both keratin-18 concentration &gt;285 U\/L and FibroTest &gt;0.74 had a 24% cumulative incidence of liver-related events at 2 years, versus 5% to 14% in other groups of patients. Similar results were obtained when combining keratin-18 concentration &gt;285 U\/L with MELD &gt;10. In patients with active alcohol consumption at enrollment (n=81), hepatocyte lEVs predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both hepatocyte lEVs concentration &gt;50 U\/L and FibroTest&gt;0.74 had a 62% cumulative incidence of liver-related events at 2 years, versus 8% to 13% in other groups of patients. Combining hepatocyte lEVs concentration &gt;50 U\/L with MELD &gt;10 had a lower discrimination ability. Similar results were obtained using as endpoint decompensation of cirrhosis defined according Baveno VII criteria.<\/p>\r\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Conclusion:\u00a0<\/strong>In patients with Child-Pugh class A alcohol-related cirrhosis, combining hepatocyte-derived biomarkers with FibroTest or MELD score identifies patients at high-risk of liver-related events, and could be used for risk stratification and patient selection in clinical trials. \u00a0 \u00a0\u00a0<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - 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