{"id":70682,"date":"2023-10-16T16:52:02","date_gmt":"2023-10-16T14:52:02","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=70682"},"modified":"2025-12-05T17:20:32","modified_gmt":"2025-12-05T16:20:32","slug":"role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/","title":{"rendered":"Role of adherent and invasive Escherichia coli in Crohn&#8217;s disease: lessons from the postoperative recurrence model"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-70682","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Gut.","date_de_publication":"20230101","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Anthony Buisson"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Harry Sokol"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nassim Hammoudi"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"St\u00e9phane Nancey"},{"texte_libre":false,"auteur-lien":13160,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maria Nachury"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mathurin Fumery"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Xavier H\u00e9buterne"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Michael Rodrigues"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gilles Boschetti"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Carmen Stefanescu"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pauline Wils"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Philippe Seksik"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lionel Le Bourhis"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Madeleine Bezault"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pierre Sauvanet"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bruno Pereira"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthieu Allez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nicolas Barnich"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Remind study group"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/35361684\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objective:\u00a0<\/strong>We used the postoperative recurrence model to better understand the role of adherent and invasive\u00a0<i>Escherichia coli<\/i>\u00a0(AIEC) bacteria in Crohn's disease (CD), taking advantage of a well-characterised postoperative cohort.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Design:\u00a0<\/strong>From a prospective, multicentre cohort of operated patients with CD, AIEC identification was performed within the surgical specimen (M0) (N=181 patients) and the neoterminal ileum (n=119 patients\/181) during colonoscopy performed 6 months after surgery (M6). Endoscopic postoperative recurrence was graded using Rutgeerts' index. The mucosa-associated microbiota was analysed by 16S sequencing at M0 and M6. Relative risks or ORs were adjusted on potential confounders.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>AIEC prevalence was twofold higher within the neoterminal ileum at M6 (30.3%) than within the surgical specimen (14.9%) (p&lt;0.001). AIEC within the neoterminal ileum at M6 was associated with higher rate of early ileal lesions (i1) (41.6% vs 17.1%; aRR 3.49 (95% CI 1.01 to 12.04), p=0.048) or ileal lesions (i2b+i3) (38.2% vs 17.1%; aRR 3.45 (95% CI 1.06 to 11.30), p=0.040) compared with no lesion (i0). AIEC within the surgical specimen was predictive of higher risk of i2b-endoscopic postoperative recurrence (POR) (aOR 2.54 (95% CI 1.01 to 6.44), p=0.049) and severe endoscopic POR (aOR 3.36 (95% CI 1.25 to 9.06), p=0.017). While only 5.0% (6\/119) of the patients were AIEC-positive at both M0 and M6, 43.7% (52\/119), patients with history of positive test for AIEC (M0 or M6) had higher risk of ileal endoscopic POR (aOR 2.32 (95% CI 1.01 to 5.39), p=0.048)), i2b-endoscopic postoperative recurrence (aOR 2.41 (95% CI 1.01 to 5.74); p=0.048) and severe endoscopic postoperative (aOR=3.84 (95% CI 1.32 to 11.18), p=0.013). AIEC colonisation was associated with a specific microbiota signature including increased abundance of\u00a0<i>Ruminococcus gnavus<\/i>.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>Based on the postoperative recurrence model, our data support the idea that AIEC are involved in the early steps of ileal CD.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objective:\u00a0<\/strong>We used the postoperative recurrence model to better understand the role of adherent and invasive\u00a0<i>Escherichia coli<\/i>\u00a0(AIEC) bacteria in Crohn's disease (CD), taking advantage of a well-characterised postoperative cohort.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Design:\u00a0<\/strong>From a prospective, multicentre cohort of operated patients with CD, AIEC identification was performed within the surgical specimen (M0) (N=181 patients) and the neoterminal ileum (n=119 patients\/181) during colonoscopy performed 6 months after surgery (M6). Endoscopic postoperative recurrence was graded using Rutgeerts' index. The mucosa-associated microbiota was analysed by 16S sequencing at M0 and M6. Relative risks or ORs were adjusted on potential confounders.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>AIEC prevalence was twofold higher within the neoterminal ileum at M6 (30.3%) than within the surgical specimen (14.9%) (p&lt;0.001). AIEC within the neoterminal ileum at M6 was associated with higher rate of early ileal lesions (i1) (41.6% vs 17.1%; aRR 3.49 (95% CI 1.01 to 12.04), p=0.048) or ileal lesions (i2b+i3) (38.2% vs 17.1%; aRR 3.45 (95% CI 1.06 to 11.30), p=0.040) compared with no lesion (i0). AIEC within the surgical specimen was predictive of higher risk of i2b-endoscopic postoperative recurrence (POR) (aOR 2.54 (95% CI 1.01 to 6.44), p=0.049) and severe endoscopic POR (aOR 3.36 (95% CI 1.25 to 9.06), p=0.017). While only 5.0% (6\/119) of the patients were AIEC-positive at both M0 and M6, 43.7% (52\/119), patients with history of positive test for AIEC (M0 or M6) had higher risk of ileal endoscopic POR (aOR 2.32 (95% CI 1.01 to 5.39), p=0.048)), i2b-endoscopic postoperative recurrence (aOR 2.41 (95% CI 1.01 to 5.74); p=0.048) and severe endoscopic postoperative (aOR=3.84 (95% CI 1.32 to 11.18), p=0.013). AIEC colonisation was associated with a specific microbiota signature including increased abundance of\u00a0<i>Ruminococcus gnavus<\/i>.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>Based on the postoperative recurrence model, our data support the idea that AIEC are involved in the early steps of ileal CD.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Role of adherent and invasive Escherichia coli in Crohn&#039;s disease: lessons from the postoperative recurrence model - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Role of adherent and invasive Escherichia coli in Crohn&#039;s disease: lessons from the postoperative recurrence model - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T16:20:32+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\",\"name\":\"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\"},\"datePublished\":\"2023-10-16T14:52:02+00:00\",\"dateModified\":\"2025-12-05T16:20:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Role of adherent and invasive Escherichia coli in Crohn&rsquo;s disease: lessons from the postoperative recurrence model\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI","og_url":"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","article_modified_time":"2025-12-05T16:20:32+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/","url":"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/","name":"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI","isPartOf":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#website"},"datePublished":"2023-10-16T14:52:02+00:00","dateModified":"2025-12-05T16:20:32+00:00","breadcrumb":{"@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.mlcom-dev.net\/publications\/"},{"@type":"ListItem","position":3,"name":"Role of adherent and invasive Escherichia coli in Crohn&rsquo;s disease: lessons from the postoperative recurrence model"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.mlcom-dev.net\/#website","url":"https:\/\/cri1149.mlcom-dev.net\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.mlcom-dev.net\/#organization","name":"CRI1149","url":"https:\/\/cri1149.mlcom-dev.net\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"post_type":"publication","author_name":"","_links":{"self":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication\/70682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/equipes\/143"}],"wp:attachment":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/media?parent=70682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}