{"id":73517,"date":"2024-05-15T15:04:18","date_gmt":"2024-05-15T13:04:18","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=73517"},"modified":"2025-12-05T17:20:08","modified_gmt":"2025-12-05T16:20:08","slug":"randall-type-monoclonal-immunoglobulin-deposition-disease-new-insights-into-the-pathogenesis-diagnosis-and-management","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/randall-type-monoclonal-immunoglobulin-deposition-disease-new-insights-into-the-pathogenesis-diagnosis-and-management\/","title":{"rendered":"Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-73517","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Diagnostics (Basel).","date_de_publication":"20210302","numero_doi":"10.3390\/diagnostics11030420","equipe":[262],"auteurs-liste":[{"texte_libre":false,"auteur-lien":71595,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Florent Joly"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Audrey Sibille"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Vincent Javaugue"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Estelle Desport"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jean-Michel Goujon"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guy Touchard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jean-Paul Fermand"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Christophe Sirac"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Frank Bridoux"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/33801393\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Randall-type monoclonal immunoglobulin deposition disease (MIDD) is a rare disease that belongs to the spectrum of monoclonal gammopathy of renal significance (MGRS). Renal involvement is prominent in MIDD, but extra-renal manifestations can be present and may affect global prognosis. Recent data highlighted the central role of molecular characteristics of nephrotoxic monoclonal immunoglobulins in the pathophysiology of MIDD, and the importance of serum free light chain monitoring in the diagnosis and follow-up disease. Clone-targeted therapy is required to improve the overall and renal survival, and the achievement of a rapid and deep hematological response is the goal of therapy. This review will focus on the recent progress in the pathogenesis and management of this rare disease.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Randall-type monoclonal immunoglobulin deposition disease (MIDD) is a rare disease that belongs to the spectrum of monoclonal gammopathy of renal significance (MGRS). Renal involvement is prominent in MIDD, but extra-renal manifestations can be present and may affect global prognosis. Recent data highlighted the central role of molecular characteristics of nephrotoxic monoclonal immunoglobulins in the pathophysiology of MIDD, and the importance of serum free light chain monitoring in the diagnosis and follow-up disease. Clone-targeted therapy is required to improve the overall and renal survival, and the achievement of a rapid and deep hematological response is the goal of therapy. This review will focus on the recent progress in the pathogenesis and management of this rare disease.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/randall-type-monoclonal-immunoglobulin-deposition-disease-new-insights-into-the-pathogenesis-diagnosis-and-management\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T16:20:08+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/randall-type-monoclonal-immunoglobulin-deposition-disease-new-insights-into-the-pathogenesis-diagnosis-and-management\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/randall-type-monoclonal-immunoglobulin-deposition-disease-new-insights-into-the-pathogenesis-diagnosis-and-management\/\",\"name\":\"Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management - 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