{"id":73523,"date":"2024-05-15T17:00:20","date_gmt":"2024-05-15T15:00:20","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&#038;p=73523"},"modified":"2025-12-05T17:20:08","modified_gmt":"2025-12-05T16:20:08","slug":"wnt-dependent-interaction-between-inflammatory-fibroblasts-and-folr2-macrophages-promotes-fibrosis-in-chronic-kidney-disease","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/wnt-dependent-interaction-between-inflammatory-fibroblasts-and-folr2-macrophages-promotes-fibrosis-in-chronic-kidney-disease\/","title":{"rendered":"WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-73523","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Nat Commun.","date_de_publication":"20240125","numero_doi":"10.1038\/s41467-024-44886-z","equipe":[262],"auteurs-liste":[{"texte_libre":false,"auteur-lien":71595,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rana Mhaidly"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Hugo Croizer"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Yann Kieffer"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Renaud Leclere"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Anne Vincent-Salomon"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Catherine Robley"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Dany Anglicheau"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marion Rabant"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Aur\u00e9lie Sannier"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marc-Olivier Timsit"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sean Eddy "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthias Kretzler "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Wenjun Ju"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fatima Mechta-Grigoriou"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/38272907\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the role of different populations is still unclear. Here, we characterize a proinflammatory fibroblast population (named CXCL-iFibro), which corresponds to an early state of myofibroblast differentiation in CKD. We demonstrate that CXCL-iFibro co-localize with macrophages in the kidney and participate in their attraction, accumulation, and switch into FOLR2+ macrophages from early CKD stages on. In vitro, macrophages promote the switch of CXCL-iFibro into ECM-secreting myofibroblasts through a WNT\/\u03b2-catenin-dependent pathway, thereby suggesting a reciprocal crosstalk between these populations of fibroblasts and macrophages. Finally, the detection of CXCL-iFibro at early stages of CKD is predictive of poor patient prognosis, which shows that the CXCL-iFibro population is an early player in CKD progression and demonstrates the clinical relevance of our findings.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the role of different populations is still unclear. Here, we characterize a proinflammatory fibroblast population (named CXCL-iFibro), which corresponds to an early state of myofibroblast differentiation in CKD. We demonstrate that CXCL-iFibro co-localize with macrophages in the kidney and participate in their attraction, accumulation, and switch into FOLR2+ macrophages from early CKD stages on. In vitro, macrophages promote the switch of CXCL-iFibro into ECM-secreting myofibroblasts through a WNT\/\u03b2-catenin-dependent pathway, thereby suggesting a reciprocal crosstalk between these populations of fibroblasts and macrophages. Finally, the detection of CXCL-iFibro at early stages of CKD is predictive of poor patient prognosis, which shows that the CXCL-iFibro population is an early player in CKD progression and demonstrates the clinical relevance of our findings.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/wnt-dependent-interaction-between-inflammatory-fibroblasts-and-folr2-macrophages-promotes-fibrosis-in-chronic-kidney-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T16:20:08+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/wnt-dependent-interaction-between-inflammatory-fibroblasts-and-folr2-macrophages-promotes-fibrosis-in-chronic-kidney-disease\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/wnt-dependent-interaction-between-inflammatory-fibroblasts-and-folr2-macrophages-promotes-fibrosis-in-chronic-kidney-disease\/\",\"name\":\"WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease - 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