{"id":73751,"date":"2024-09-12T15:40:18","date_gmt":"2024-09-12T13:40:18","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&p=73751"},"modified":"2025-12-05T17:20:00","modified_gmt":"2025-12-05T16:20:00","slug":"fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/","title":{"rendered":"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation"},"content":{"rendered":"","protected":false},"featured_media":73752,"template":"","meta":{"_acf_changed":false},"class_list":["post-73751","publication","type-publication","status-publish","has-post-thumbnail","hentry"],"acf":{"numero_de_publication":"Gut Microbes.","date_de_publication":"20240903","numero_doi":"10.1080\/19490976.2024.2394249","equipe":[0],"auteurs-liste":[{"texte_libre":false,"auteur-lien":16388,"auteur-text":""},{"texte_libre":false,"auteur-lien":13149,"auteur-text":""},{"texte_libre":false,"auteur-lien":69524,"auteur-text":""},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Chunhua Yang"},{"texte_libre":false,"auteur-lien":13113,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Katell Peoc'h"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Benoit Chassaing"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Didier Merlin"},{"texte_libre":false,"auteur-lien":14593,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.insermbiblio.inist.fr\/39224018\/"}],"paragraphe":"

Une nouvelle \u00e9tude de l'\u00e9quipe de Viennois, men\u00e9e par Maite Casador-Bedmar, a mis en \u00e9vidence que des microARN f\u00e9caux, let-7b et miR-21, conduisaient \u00e0 une inflammation intestinale en modifiant la composition du microbiote.<\/p>\r\n

Cette \u00e9tude montre que ces microARN, dont le taux sont \u00e9lev\u00e9s dans les selles des patients et les mod\u00e8les murins de colite, peuvent fa\u00e7onner le microbiote intestinal de mani\u00e8re directe et induire l'inflammation caract\u00e9ristique des MICI. Ces microARN perturbent le microbiote intestinal, augmentent la r\u00e9ponse pro-inflammatoire et affaiblissent la fonction de barri\u00e8re. \u00c0 l'inverse, l\u2019inhibition de ces micro-ARN r\u00e9duit l'inflammation et am\u00e9liore la sant\u00e9 intestinale, sugg\u00e9rant ainsi ces mol\u00e9cules comme de nouvelles cibles th\u00e9rapeutiques dans les MICI et r\u00e9tablir l'\u00e9quilibre du microbiome intestinal.<\/p>\r\n

\"\"<\/p>","paragraphe_en":"

New study led by Emilie Viennois and conducted by Maite Casador-Bedmar uncovers how specific fecal microRNAs, let-7b and miR-21, drive gut inflammation by altering microbiota composition. This study shows that let-7b and miR-21, found to be elevated in stool from patients and mouse models, can directly shape the gut microbiota and drive inflammation in IBD. These microRNAs were found to disrupt the balance of gut bacteria, increase proinflammatory r esponses, and weaken the intestinal barrier. Conversely, blocking these miRANs reduced inflammation and improved gut health, unveiling a new therapeutic target to fight IBD and restoring balance to the gut microbiome.<\/p>\r\n

\"\"<\/p>","documents":null},"yoast_head":"\nFecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T16:20:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png\" \/>\n\t<meta property=\"og:image:width\" content=\"624\" \/>\n\t<meta property=\"og:image:height\" content=\"499\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/\",\"name\":\"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png\",\"datePublished\":\"2024-09-12T13:40:18+00:00\",\"dateModified\":\"2025-12-05T16:20:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png\",\"contentUrl\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png\",\"width\":624,\"height\":499},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.mlcom-dev.net\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#website\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l'Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI","og_url":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","article_modified_time":"2025-12-05T16:20:00+00:00","og_image":[{"width":624,"height":499,"url":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/","url":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/","name":"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation - CRI","isPartOf":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#website"},"primaryImageOfPage":{"@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage"},"image":{"@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage"},"thumbnailUrl":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png","datePublished":"2024-09-12T13:40:18+00:00","dateModified":"2025-12-05T16:20:00+00:00","breadcrumb":{"@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#primaryimage","url":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png","contentUrl":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2024\/09\/New-study-led-by-Emilie-Viennois-and-conducted-by-Maite-Casador.png","width":624,"height":499},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.mlcom-dev.net\/publication\/fecal-let-7b-and-mir-21-directly-modulate-the-intestinal-microbiota-driving-chronic-inflammation\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.mlcom-dev.net\/en\/cri-home\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.mlcom-dev.net\/publications\/"},{"@type":"ListItem","position":3,"name":"Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.mlcom-dev.net\/#website","url":"https:\/\/cri1149.mlcom-dev.net\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l'Inflammation","publisher":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.mlcom-dev.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.mlcom-dev.net\/#organization","name":"CRI1149","url":"https:\/\/cri1149.mlcom-dev.net\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.mlcom-dev.net\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.mlcom-dev.net\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"post_type":"publication","author_name":"","_links":{"self":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication\/73751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/media\/73752"}],"wp:attachment":[{"href":"https:\/\/cri1149.mlcom-dev.net\/en\/wp-json\/wp\/v2\/media?parent=73751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}