{"id":74182,"date":"2025-02-19T12:40:51","date_gmt":"2025-02-19T11:40:51","guid":{"rendered":"https:\/\/cri1149.mlcom-dev.net\/?post_type=publications&p=74182"},"modified":"2025-12-05T17:19:43","modified_gmt":"2025-12-05T16:19:43","slug":"enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome","status":"publish","type":"publication","link":"https:\/\/cri1149.mlcom-dev.net\/en\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","title":{"rendered":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"class_list":["post-74182","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Cell Rep.","date_de_publication":"20230920","numero_doi":"10.1016\/j.celrep.2023.112990","equipe":[273],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Christine Quach"},{"texte_libre":false,"auteur-lien":73990,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Meng Li"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Benjamin Pierre Hurrell"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Emily Howard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pedram Shafiei-Jahani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pejman Soroosh"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jing-hsiung James Ou"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Babak Razani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Virender Rehan"},{"texte_libre":true,"auteur-lien":null,"auteur-text":" Omid Akbari"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10510741\/"}],"paragraphe":"

SUMMARY<\/h2>\r\n

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical disorders that mainly develop from viral respiratory infections, sepsis, and chest injury. Antigen-presenting cells play a pivotal role in propagating uncontrolled inflammation and injury through the excess secretion of pro-inflammatory cytokines and recruitment of immune cells. Autophagy, a homeostatic process that involves the degradation of cellular components, is involved in many processes including lung inflammation. Here, we use a polyinosinic-polycytidylic acid (poly(I:C))-induced lung injury mouse model to mimic viral-induced ALI\/ARDS and show that disruption of autophagy in macrophages exacerbates lung inflammation and injury, whereas autophagy induction attenuates this process. Therefore, induction of autophagy in macrophages can be a promising therapeutic strategy in ALI\/ARDS.<\/p>","paragraphe_en":"

SUMMARY<\/h2>\r\n

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical disorders that mainly develop from viral respiratory infections, sepsis, and chest injury. Antigen-presenting cells play a pivotal role in propagating uncontrolled inflammation and injury through the excess secretion of pro-inflammatory cytokines and recruitment of immune cells. Autophagy, a homeostatic process that involves the degradation of cellular components, is involved in many processes including lung inflammation. Here, we use a polyinosinic-polycytidylic acid (poly(I:C))-induced lung injury mouse model to mimic viral-induced ALI\/ARDS and show that disruption of autophagy in macrophages exacerbates lung inflammation and injury, whereas autophagy induction attenuates this process. Therefore, induction of autophagy in macrophages can be a promising therapeutic strategy in ALI\/ARDS.<\/p>","documents":null},"yoast_head":"\nEnhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.mlcom-dev.net\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-05T16:19:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/\",\"url\":\"https:\/\/cri1149.mlcom-dev.net\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/\",\"name\":\"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - 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