Auteurs
Jean-Baptiste Bachet,
Alexandre Harlé,
Juan Iovanna,
Anthony Turpin,
Meher Ben Abdelghani,
Alice Wei,
Emmanuel Mitry,
Anthony Lopez,
James Biagi,
Eric François,
Pascal Artru,
Aurélien Lambert,
Daniel J Renouf,
Laure Monard,
Marjorie Mauduit,
Nelson Dusetti,
Thierry Conroy,
This study evaluates the value of a transcriptomic signature, GemPred, to predict gemcitabine sensitivity in patients with resected pancreatic ductal adenocarcinoma (PDAC). This signature provides evidence of the possibility to uncover and apply clinically phenotyping tools for personalized medicine.
The study demonstrated that patients classified as GemPred+, indicating a high likelihood of gemcitabine response, experienced significantly better disease-free and cancer-specific survival compared to those categorized as GemPred–. GemPred+ patients exhibited similar survival outcomes regardless of whether they received gemcitabine or a more aggressive chemotherapy regimen.
These findings highlight the potential of GemPred and more generally the transcriptome to guides patient treatment decisions, enabling to select the most effective and least toxic therapy for each individual patient.
Autres publications
Date de publication :
11 Fév 2025Auteurs :
Hilmi Marc,
Flore Delecourt,
Raffenne Jérome,
Bourega Taib,
Nelson Dusetti,
Juan Iovanna,
Yuna Blum,
Magali Richard,
Cindy Neuzillet,
Couvelard Anne,
Matthieu Tihy,
De Mestier Louis,
Rebours Vinciane,
Nicolle Rémy,
Cros Jérome,
Date de publication :
04 Oct 2024Auteurs :
Yohann Loriot,
Maud Kamal,
Laurene Syx,
Nicolle Rémy,
Celia Dupain,
Naoual Mensourri,
Igor Duquesne,
Pernelle Lavaud,
Claudio Nicotra,
Maud Ngocamus,
Ludovic Lacroix,
Lambros Tselikas,
Gilles Crehange,
Luc Friboulet,
Zahra Castel-Ajgal,
Yann Neuzillet,
Edith Borcoman,
Philippe Beuzeboc,
Grégoire Marret,
Tom Gutman,
Jennifer Wong,
Francois Radvanyi,
Sylvain Dureau,
Jean-Yves Scoazec,
Nicolas Servant,
Yves Allory,
Benjamin Besse,
Fabrice Andre,
Christophe Le Tourneau,
Christophe Massard,
Ivan Bieche,
The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy
Lancet Gastroenterol Hepatol.
Date de publication :
01 Déc 2023Auteurs :
Hilmi Marc,
Matthieu Delaye,
Milena Muzzolini,
Nicolle Rémy,
Cros Jérome,
Hammel Pascal,
Victoire Cardot-Ruffino,
Cindy Neuzillet,
Date de publication :
05 Jan 2022Auteurs :
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Paradis Valérie,
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Nicolle Rémy,
Cros Jérome,